A novel digital paradigm of orientation is associated with amyloid and tau among cognitively unimpaired individuals

Orientation in time, space, and person is often impaired in Alzheimer’s disease dementia. Subtle changes in orientation may occur in prodromal and preclinical disease stages. Here we aim to assess the cross-sectional association between individuals’ orientation to their own world, as measured with a novel AI-based paradigm, and Alzheimer’s disease biomarkers (amyloid and tau) in cognitively unimpaired older adults.